Opportunity Information: Apply for CDC RFA GH22 2229
The Soroti Regional Mechanism for Reaching and Sustaining Epidemic Control in the Republic of Uganda is a PEPFAR-funded grant opportunity issued by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), under Funding Opportunity Number CDC RFA GH22 2229 (CFDA 93.067). It is structured as a cooperative agreement, meaning the selected recipient would not only receive funding but would also work closely with CDC through substantial involvement in planning, implementation support, and performance monitoring. The opportunity was posted on December 30, 2021, with an application deadline of February 28, 2022 (applications due by 11:59 pm ET). Eligibility is listed as unrestricted, effectively open to a wide range of applicant types as long as they meet any additional eligibility conditions described in the full announcement.
The program focus is epidemic control for HIV in Uganda’s Soroti Region through a comprehensive package of HIV and tuberculosis (TB) prevention, care, and treatment services. The overall intent is to strengthen and sustain a decentralized regional response by improving how services are found, delivered, tracked, and maintained over time. The work is designed to push progress toward the global HIV treatment goals known as 95-95-95: 95 percent of people living with HIV know their status, 95 percent of those diagnosed are on antiretroviral therapy (ART), and 95 percent of those on ART achieve viral suppression. In practical terms, the NOFO emphasizes both finding people who do not yet know they are living with HIV and keeping those already diagnosed consistently engaged in high-quality treatment until they reach and maintain viral suppression.
A central part of the planned approach is intensified HIV case finding, with explicit attention to populations that are often underserved or harder to reach in routine systems. The description highlights men, young people, and key populations (KP) as priority groups for testing and linkage strategies. Alongside diagnosis, the grant supports the full cascade of HIV care and treatment, including same-day or rapid linkage to ART where feasible, retention interventions, and ongoing clinical management. Because TB remains a major cause of illness and death among people living with HIV, the opportunity also integrates TB prevention, diagnosis, and treatment as a routine part of HIV programming rather than as a separate vertical service.
The NOFO includes several targeted service components that reflect current best practices in HIV epidemic control. Prevention of mother-to-child transmission (PMTCT) is a major pillar, focusing on identifying HIV among pregnant and breastfeeding women, initiating and sustaining ART, ensuring infant testing and follow-up, and closing gaps that lead to missed diagnoses or treatment interruptions. It also calls for improved management of advanced HIV disease (AHD), which typically involves earlier identification of severely immunocompromised patients and rapid delivery of appropriate diagnostics and interventions to prevent opportunistic infections and reduce mortality. In addition, the program expects integration of non-communicable disease (NCD) services with HIV care to make service delivery more convenient and patient-centered, recognizing that long-term HIV care increasingly overlaps with chronic disease screening and management needs.
On the prevention side, the opportunity explicitly supports voluntary medical male circumcision (VMMC) as a proven HIV prevention intervention, as well as pre-exposure prophylaxis (PrEP) for individuals at substantial risk of acquiring HIV. These prevention services are intended to complement testing and treatment efforts by reducing new infections, which is essential for sustaining epidemic control once high treatment coverage is achieved. The NOFO also emphasizes the laboratory backbone and strategic information (SI) systems needed to run a high-performing program. This includes viral load (VL) testing to measure treatment effectiveness and guide clinical decision-making, as well as recency surveillance, which helps programs better understand recent transmission patterns and direct prevention and case-finding resources more effectively.
Implementation is framed as a health systems strengthening effort rather than a short-term campaign. The selected recipient is expected to work in close coordination with Uganda’s Ministry of Health (MOH) to build the capacity of Regional Referral Hospitals (RRH) and district-level systems so that services can be delivered effectively at decentralized points of care and sustained over time. The NOFO also signals a strong role for faith-based and community-based partners to improve people-centered service delivery, which typically includes community mobilization, peer and community health worker models, stigma reduction, support for adherence and retention, and improved linkage between community and facility services.
In terms of funding, CDC indicates an approximate total fiscal year funding amount of $15,000,000 for Year 1, contingent on the availability of funds, with an expectation of making one award. Notably, the announcement lists an award ceiling of $0 for Year 1; this type of listing often reflects an administrative or reporting convention in the posted notice rather than an indication that no funds will be awarded, especially since CDC separately states an anticipated total funding amount for Year 1. The core expectation is that the award will enable measurable improvements in access, quality, and coverage across the HIV and TB service continuum in Soroti Region, with performance ultimately judged by progress toward the 95-95-95 benchmarks and by the strength and durability of the regional health system capacity built through the project.Apply for CDC RFA GH22 2229
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Soroti Regional Mechanism for Reaching and Sustaining Epidemic Control in the Republic of Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Dec 30, 2021.
- Applicants must submit their applications by Feb 28, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
1. What is the Soroti Regional Mechanism for Reaching and Sustaining Epidemic Control in Uganda?
It is a PEPFAR-funded grant opportunity focused on strengthening and sustaining HIV epidemic control in Uganda's Soroti Region through a comprehensive package of HIV and tuberculosis (TB) prevention, care, and treatment services.
2. Which U.S. agency is offering this grant?
The opportunity is issued by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
3. What is the Funding Opportunity Number (NOFO/FON) for this announcement?
The Funding Opportunity Number is CDC RFA GH22 2229.
4. What is the CFDA number listed for this opportunity?
The CFDA number listed is 93.067.
5. What type of award is this (grant vs. cooperative agreement)?
This opportunity is structured as a cooperative agreement. That means the selected recipient would receive funding and also work closely with CDC, with CDC having substantial involvement in planning, implementation support, and performance monitoring.
6. When was the opportunity posted?
The opportunity was posted on December 30, 2021.
7. What was the application deadline?
The application deadline was February 28, 2022, with applications due by 11:59 pm Eastern Time (ET).
8. Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is effectively open to a wide range of applicant types, as long as they meet any additional eligibility conditions described in the full announcement.
9. What region is the program focused on?
The program is focused on Uganda's Soroti Region.
10. What is the main goal of the project?
The main goal is to help reach and sustain HIV epidemic control in Soroti Region by improving how HIV and TB services are found, delivered, tracked, and maintained over time through a decentralized regional response.
11. What does "95-95-95" mean in this opportunity?
95-95-95 refers to global HIV treatment goals: 95 percent of people living with HIV know their status, 95 percent of those diagnosed are on antiretroviral therapy (ART), and 95 percent of those on ART achieve viral suppression.
12. What does the NOFO emphasize in practical terms for reaching 95-95-95?
It emphasizes intensified HIV case finding (especially identifying people who do not yet know they are living with HIV) and keeping those already diagnosed consistently engaged in high-quality treatment until they reach and maintain viral suppression.
13. Which populations are highlighted as priorities for HIV testing and linkage strategies?
The description highlights men, young people, and key populations (KP) as priority groups for testing and linkage strategies.
14. What HIV treatment and care activities are supported?
The opportunity supports the full HIV care and treatment cascade, including same-day or rapid linkage to ART where feasible, retention interventions, ongoing clinical management, and viral load monitoring to assess treatment effectiveness.
15. How is TB addressed within this HIV program?
TB prevention, diagnosis, and treatment are integrated as a routine part of HIV programming rather than treated as a separate vertical service, recognizing TB as a major cause of illness and death among people living with HIV.
16. What is PMTCT and how does it fit into this opportunity?
PMTCT stands for prevention of mother-to-child transmission. It is a major pillar of the program and focuses on identifying HIV among pregnant and breastfeeding women, initiating and sustaining ART, ensuring infant testing and follow-up, and closing gaps that lead to missed diagnoses or treatment interruptions.
17. What is "advanced HIV disease (AHD)" management in the context of this NOFO?
The NOFO calls for improved management of advanced HIV disease, which typically involves earlier identification of severely immunocompromised patients and rapid delivery of appropriate diagnostics and interventions to prevent opportunistic infections and reduce mortality.
18. Does the opportunity include services beyond HIV and TB?
Yes. It expects integration of non-communicable disease (NCD) services with HIV care to make service delivery more convenient and patient-centered.
19. Which HIV prevention interventions are specifically supported?
The opportunity explicitly supports voluntary medical male circumcision (VMMC) and pre-exposure prophylaxis (PrEP) for individuals at substantial risk of acquiring HIV.
20. What laboratory services are emphasized?
Viral load (VL) testing is emphasized as a key laboratory service to measure treatment effectiveness and guide clinical decision-making.
21. What is "strategic information (SI)" and what does it include here?
Strategic information (SI) refers to the systems and data capabilities needed to run a high-performing program. In this opportunity, it includes a focus on laboratory backbone and SI systems such as viral load monitoring and recency surveillance to better understand transmission patterns and target resources.
22. What is recency surveillance and why is it included?
Recency surveillance is described as a tool to help programs better understand recent HIV transmission patterns, so prevention and case-finding resources can be directed more effectively.
23. What does "decentralized regional response" mean in this NOFO?
It refers to strengthening the ability of regional and district systems to deliver services effectively at decentralized points of care, rather than relying only on centralized services.
24. How does the recipient coordinate with the Government of Uganda?
The selected recipient is expected to work in close coordination with Uganda's Ministry of Health (MOH) to build capacity of Regional Referral Hospitals (RRH) and district-level systems.
25. What role do faith-based and community-based partners play in the approach?
The NOFO signals a strong role for faith-based and community-based partners to improve people-centered service delivery, typically including community mobilization, peer and community health worker models, stigma reduction, adherence and retention support, and better linkage between community and facility services.
26. How much funding is expected for Year 1?
CDC indicates an approximate total fiscal year funding amount of $15,000,000 for Year 1, contingent on the availability of funds.
27. How many awards does CDC expect to make?
The announcement indicates an expectation of making one award.
28. Why does the announcement list an award ceiling of $0 for Year 1?
The notice lists an award ceiling of $0 for Year 1, which is described as something that often reflects an administrative or reporting convention in the posted notice rather than an indication that no funds will be awarded, particularly since CDC also states an anticipated total funding amount for Year 1.
29. What does CDC's "substantial involvement" look like in a cooperative agreement?
Based on the description provided, CDC would be involved in planning, providing implementation support, and monitoring performance, working closely with the recipient rather than acting only as a funder.
30. How will performance and success be judged for this project?
Performance is ultimately tied to measurable improvements in access, quality, and coverage across the HIV and TB service continuum in Soroti Region, progress toward the 95-95-95 benchmarks, and the strength and durability of regional health system capacity built through the project.
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