Opportunity Information: Apply for HT942524KCRPCA
The FY24 DoD Kidney Cancer Research Program (KCRP) Concept Award is a small, high-impact research grant designed to back bold, untested ideas in kidney cancer rather than incremental extensions of existing projects. The intent is to give investigators room to chase genuinely novel concepts, including promising "serendipitous" observations, with the expectation that the work could open entirely new research directions. A key rule is that preliminary data are not allowed and should not be included or even discussed in the application, reinforcing that this mechanism is for early-stage, high-risk thinking rather than proposals built around established datasets.
Projects funded through this award are expected to clearly explain how the idea will expand what is known about kidney cancer or create a new, innovative line of investigation. While the award itself is not meant to fund large, mature programs, it is positioned as a springboard: successful Concept Award results may produce the kind of early evidence that can later support more substantial follow-on proposals under other funding opportunities.
The program also highlights several broad, organizational-level emphasis areas that applicants may align with when appropriate. One emphasis is nuclear medicine, encouraging innovative uses of nuclear medicine and related techniques to improve early diagnosis, enable more effective treatment, and strengthen outcomes, particularly for active-duty Service Members and their families. Another emphasis is women's health, encouraging research on conditions that affect women uniquely, disproportionately, or differently than men, including thoughtful analysis of sex as a biological variable and a clear link between anticipated findings and improvements in women's health outcomes. The opportunity also points to the Metastatic Cancer Task Force recommendations and encourages applicants to propose ideas that help accelerate clinical and translational progress for advanced or recurrent disease, as long as the ideas fit within this award's boundaries and the KCRP's stated priorities. Across all topics, rigorous study design is stressed, with expectations around practices that improve reproducibility and translation, such as appropriate randomization, blinding when relevant, sample-size estimation, and transparent data handling and reporting.
Collaboration with the military and other federal partners is strongly encouraged. Applications from investigators within the military services, and multidisciplinary teams spanning academia, industry, the military, the Department of Veterans Affairs, and other agencies, are seen as especially valuable because they can bring specialized infrastructure and access to unique populations or resources. If a project depends on special resources or databases, the application needs to explain what access already exists at submission and how access will be maintained throughout the project. Review will be blinded to the identities of the principal investigator, collaborators, and organizations, meaning proposals must be written so that scientific merit stands on its own without relying on reputation or institutional prestige.
Clinical trials are not allowed under this funding opportunity. The announcement uses the federal regulatory definition of a clinical trial (45 CFR 46.102), focusing on prospective assignment of human subjects to interventions to measure intervention effects on health outcomes. However, observational clinical research is allowed, including work involving human data, specimens, or interaction with human subjects as long as it does not evaluate the safety, effectiveness, or efficacy of an intervention. Examples of allowable clinical research include studies on disease mechanisms, diagnostic or detection approaches such as biomarkers or imaging, health disparities, technology development, epidemiology and behavioral studies that are non-interventional, and certain outcomes or health services research that do not meet the clinical trial definition. The announcement also clarifies that some in vitro studies using non-identifiable human materials may fall outside the clinical research definition if they meet Common Rule exemption criteria.
Administratively, awards will be made as grants (under 31 USC 6304) by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA). Eligibility is listed as unrestricted. The anticipated budget is modest: direct costs for the entire period of performance should not exceed $100,000. The program expects to allocate about $1.44 million total to fund approximately nine awards, with funding dependent on federal appropriations, application volume, and outcomes of peer and programmatic review. The original closing date listed for the opportunity is September 5, 2024, and awards supported with FY24 funds are expected to be made no later than September 30, 2025. Funds are anticipated to come from FY24 appropriations and are available for use only within the period before expiration, which is noted as September 30, 2030. The opportunity is identified by Funding Opportunity Number HT942524KCRPCA and is categorized under CFDA 12.420 for science and technology research and development funding.Apply for HT942524KCRPCA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Kidney Cancer, Concept Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2024-06-26.
- Applicants must submit their applications by 2024-09-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 9 candidate(s).
- Eligible applicants include: Unrestricted.
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FY24 DoD Kidney Cancer Research Program (KCRP) Concept Award (HT942524KCRPCA) FAQs
1) What is the FY24 DoD KCRP Concept Award?
The FY24 DoD Kidney Cancer Research Program (KCRP) Concept Award is a small, high-impact research grant meant to support bold, untested ideas in kidney cancer. It is designed for genuinely novel concepts, including promising "serendipitous" observations, rather than incremental extensions of existing projects.
2) What is the main goal of this Concept Award mechanism?
The goal is to give investigators room to pursue early-stage, high-risk thinking that could expand what is known about kidney cancer or create an entirely new and innovative line of investigation. It is positioned as a springboard for generating early evidence that may later support follow-on proposals under other funding opportunities.
3) Are preliminary data allowed in the application?
No. Preliminary data are not allowed and should not be included or even discussed in the application. This is a key rule intended to keep the focus on novel, untested ideas rather than proposals built around established datasets.
4) What types of research ideas are a good fit for this award?
Ideas are expected to be high-impact and innovative, with a clear explanation of how the proposed concept will expand knowledge about kidney cancer or open a new direction for research. The award is not meant to support large, mature research programs.
5) Does the opportunity include specific research emphasis areas?
Yes. The program highlights broad emphasis areas that applicants may align with when appropriate, including nuclear medicine and women's health, and it also encourages ideas aligned with the Metastatic Cancer Task Force recommendations, as long as they fit within this award's boundaries and KCRP priorities.
6) What does the nuclear medicine emphasis area encourage?
The nuclear medicine emphasis encourages innovative uses of nuclear medicine and related techniques to improve early diagnosis, enable more effective treatment, and strengthen outcomes, particularly for active-duty Service Members and their families.
7) What does the women's health emphasis area encourage?
The women's health emphasis encourages research on conditions that affect women uniquely, disproportionately, or differently than men. It also encourages thoughtful analysis of sex as a biological variable and a clear link between anticipated findings and improvements in women's health outcomes.
8) How do the Metastatic Cancer Task Force recommendations relate to this award?
The opportunity points to the Metastatic Cancer Task Force recommendations and encourages applicants to propose concepts that accelerate clinical and translational progress for advanced or recurrent disease, as long as the ideas remain within the Concept Award scope and the KCRP's stated priorities.
9) Are there expectations for study rigor and reproducibility?
Yes. Rigorous study design is emphasized, including practices that improve reproducibility and translation. Examples mentioned include appropriate randomization, blinding when relevant, sample-size estimation, and transparent data handling and reporting.
10) Is collaboration encouraged, including with military or federal partners?
Yes. Collaboration with the military and other federal partners is strongly encouraged. Multidisciplinary teams spanning academia, industry, the military, the Department of Veterans Affairs, and other agencies are viewed as especially valuable due to access to specialized infrastructure and unique populations or resources.
11) What if my project depends on special resources or databases?
If the project depends on special resources or databases, the application needs to explain what access already exists at the time of submission and how access will be maintained throughout the project.
12) Is the review process blinded?
Yes. Review will be blinded to the identities of the principal investigator, collaborators, and organizations. Proposals must be written so the scientific merit stands on its own without relying on reputation or institutional prestige.
13) Are clinical trials allowed under this funding opportunity?
No. Clinical trials are not allowed.
14) How does the opportunity define a clinical trial?
The announcement uses the federal regulatory definition of a clinical trial under 45 CFR 46.102, focusing on the prospective assignment of human subjects to interventions to measure the effects of those interventions on health outcomes.
15) Is any human-related research allowed if clinical trials are prohibited?
Yes. Observational clinical research is allowed, including work involving human data, specimens, or interaction with human subjects, as long as it does not evaluate the safety, effectiveness, or efficacy of an intervention.
16) What are examples of allowable clinical research under this award?
Examples explicitly described as allowable include studies of disease mechanisms; diagnostic or detection approaches such as biomarkers or imaging; health disparities research; technology development; epidemiology and behavioral studies that are non-interventional; and certain outcomes or health services research that do not meet the clinical trial definition.
17) Are in vitro studies using human materials allowed?
The announcement clarifies that some in vitro studies using non-identifiable human materials may fall outside the clinical research definition if they meet Common Rule exemption criteria.
18) What is the award type and which office makes the awards?
Awards will be made as grants (under 31 USC 6304) by the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA).
19) Who is eligible to apply?
Eligibility is listed as unrestricted.
20) What is the maximum budget for an individual award?
Direct costs for the entire period of performance should not exceed $100,000.
21) How much total funding is expected, and how many awards are anticipated?
The program expects to allocate about $1.44 million total to fund approximately nine awards. Funding depends on federal appropriations, application volume, and outcomes of peer and programmatic review.
22) What is the closing date for the opportunity?
The original closing date listed is September 5, 2024.
23) By when are awards expected to be made?
Awards supported with FY24 funds are expected to be made no later than September 30, 2025.
24) What fiscal year are the funds anticipated to come from, and when do they expire?
Funds are anticipated to come from FY24 appropriations and are available for use only within the period before expiration, which is noted as September 30, 2030.
25) What is the Funding Opportunity Number (FON) and CFDA number?
The Funding Opportunity Number is HT942524KCRPCA. The opportunity is categorized under CFDA 12.420 for science and technology research and development funding.
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