Opportunity Information: Apply for RFA HL 20 001

The Career Pathway to Independence in Blood Science Award for Physician Scientists (K99/R00, Independent Clinical Trial Not Allowed) is a National Heart, Lung, and Blood Institute (NHLBI) funding opportunity from the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services. Its central goal is to strengthen the pipeline of physician-scientists in blood science by helping exceptionally promising researchers move from a mentored training phase into fully independent faculty careers. The program is specifically built to create a steady cohort of new, NHLBI-supported investigators who can establish and sustain independent research programs in blood science, positioning them to compete successfully for future research funding and long-term academic advancement.

This award uses the K99/R00 "pathway to independence" structure. The K99 phase supports a time-limited, mentored research period intended for advanced postdoctoral or equivalent mentored positions, during which the awardee builds the scientific foundation, productivity, and independence needed to secure a tenure-track (or equivalent) faculty position. After successfully transitioning to an eligible independent position, the awardee may seek the companion R00 phase through a separate, associated funding opportunity announcement. The R00 phase is designed to provide support as the investigator launches an independent research program, helping bridge the critical early years of a new faculty appointment when establishing a lab, generating data, and publishing as a senior investigator are essential.

A defining feature of this specific announcement is that independent clinical trials are not allowed, meaning applicants must propose research that does not involve leading an independent clinical trial as defined by NIH policy. While clinical research activities may sometimes be included depending on NIH definitions and the specifics of the project, the intent here is to support blood science research trajectories that do not hinge on running an independent trial, keeping the focus on developing the investigator's independent research direction in blood science under mentored-to-independent career development mechanisms.

Administratively, the opportunity is identified as RFA-HL-20-001 and is categorized as a discretionary grant in the health activity area under CFDA number 93.839. The announcement was created on December 3, 2018, with an original closing date of May 8, 2020. NHLBI anticipated making about five awards under this opportunity. The listed award ceiling is shown as 0, which typically indicates that a specific maximum dollar cap is not provided in the summarized listing and that applicants should rely on the full announcement and NIH policy guidance for budget structure and limits.

Eligibility for applicant organizations is broad and includes many types of U.S. entities that commonly serve as NIH applicant institutions. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (other than higher education institutions), for-profit organizations (other than small businesses), small businesses, and a wide range of governmental entities such as state, county, and city governments, special district governments, and independent school districts. The list also includes federally recognized Native American tribal governments, tribal organizations (other than federally recognized tribal governments), and public housing authorities/Indian housing authorities, along with an "other" category that points applicants to additional eligibility clarifications in the full text.

In practical terms, this funding opportunity is meant for clinician-researchers with a clinical doctorate who have demonstrated strong potential in blood science and who are ready for a structured, supported push toward independence. The award is intended to accelerate the timeline from mentored research to a stable, independent faculty role and to provide a clear, two-step funding runway (K99 then R00 via the related announcement) that helps recipients establish themselves as competitive, independent investigators in blood science.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Career Pathway to Independence in Blood Science Award for Physician Scientists (K99/R00 Independent Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839.
  • This funding opportunity was created on Dec 03, 2018.
  • Applicants must submit their applications by May 08, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 5 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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